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Antihistamines for Morning Sickness

Topic Overview

Certain antihistamines such as dimenhydrinate or doxylamine, taken as your doctor advises, may relieve morning sickness.1 Doxylamine (Unisom SleepTabs) is available over-the-counter. If one of these antihistamines alone does not relieve your morning sickness, you can try taking it with vitamin B6.2 Talk to your doctor about the right dose.

Note: Do not confuse Unisom SleepTabs with Unisom SleepGels, which contain a different medicine.

A prescription medicine that combines doxylamine and vitamin B6 in one medicine (called Diclegis) is also available to treat morning sickness.

Common side effects of these medicines may include:

  • Drowsiness.
  • Dry mouth, nose, or throat.
  • Stomach upset.

References

Citations

  1. Festin M (2009). Nausea and vomiting in early pregnancy, search date May 2008. BMJ Clinical Evidence. Available online: http://www.clinicalevidence.com.
  2. Kelly TF, Savides TJ. (2009). Gastrointestinal disease in pregnancy. In RK Creasy et al., eds., Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice, 6th ed., pp. 1041–1057. Philadelphia: Saunders Elsevier.

Credits

By Healthwise Staff
Primary Medical Reviewer Sarah Marshall, MD - Family Medicine
Specialist Medical Reviewer Kirtly Jones, MD - Obstetrics and Gynecology
Current as of June 4, 2014

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.

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Antihistamines for Morning Sickness